Researchers Seek Clear Answers about Thyroid Cancer in Young People

Bucking the overarching trend of declining cancer rates, thyroid cancer has seen a sharp and mysterious resurgence over the last decade. Particularly troubling has been the disproportionately high rates of thyroid cancer seen among young adults, adolescents, and even children.

The scientific community is deeply divided over the origins of this disturbing trend. Although some researchers have connected it to the larger spike in overall thyroid cancer rates, others contend that there may unique strains of thyroid cancer to which younger people, for a variety of reasons, may be especially vulnerable.

One groundbreaking study conducted by Italian researchers seems to support this argument. The study found that younger people with thyroid cancer seem more prone to metastasis of the disease, meaning that the cancer often spreads throughout the body before a definitive diagnosis is made, making the possibility of recovery and survival less likely.

While the origins of highly aggressive thyroid cancer among young people remain controversial, research into this problem has been a major focus of worldwide thyroid cancer study in recent years. This week, we’ll survey some of the most significant recent findings that have emerged as scientists struggle to solve the thyroid cancer mystery.

Genetic Mutations Not Likely Cause of Aggressive Thyroid Cancer in Young

As scientists around the world have focused their efforts on investigating the factors that cause aggressive, fast-spreading, and difficult-to-diagnose cases of thyroid cancer among young adults and adolescents, some progress has been made by eliminating a number of possibilities.

A research team at the Department of Pediatrics of the University of the Health Sciences, in Bethesda, Maryland considered the possibility that certain genetic mutations may play a role in aggravating thyroid cancers in young patients. Specifically, the team focused on isolating and identifying specific mutations, such as a genetic quirk that has been linked to other types of aggressive, early-developing cancers, including breast cancer.

However, according to the team’s findings, the BRAF mutation does not appear to play a central role in papillary thyroid cancers among younger patients. Although the researchers suggest that other genetic factors may indeed play a role in the origin and progression of thyroid cancers in young people, this type of problem appears to have been statistically eliminated as a possible cause.

New Inroads in Early Detection of Thyroid Cancer Crucial to Positive Prognoses for Young Patients

Because papillary thyroid cancer tends to spread quickly without many clear symptoms in young people, researchers have exerted a great deal of effort trying to develop more effective methods of detecting the disease in its earliest stages.

In general, cases of papillary thyroid cancer progress at a different rate in younger patients than they do in their older counterparts. As such, researchers have focused on developing early detection strategies that could help yield a positive diagnosis as early as possible.

The study, published in a recent volume of the journal Otolaryngology: Head and Neck Surgery, classified the growth rates of several types of thyroid cancer among younger patients. The authors also found that the patient’s age at the time of diagnosis, rather than the size of the tumor, correlated most strongly with positive treatment outcome.

Surgical Procedure Can Prevent Thyroid Cancer in At-Risk Children and Adolescents

Medullary thyroid cancer can be deadly when undiagnosed in children and adolescents. Although this type of cancer is rare in the general population, individuals with one of several genetic mutations are at very high risk of developing the disease.

In a study conducted by researchers at Duke University, it was found that a preemptive surgical procedure may be the best way to prevent medullary thyroid cancer in children who possess this rare genetic mutation. Of the children who submitted to the surgery, virtually all remained cancer-free for a period of five years after the removal of their thyroid glands.

Although this option may appear severe, the researchers reiterated their opinion that preemptive surgical removal of the thyroid gland remains the best option for children who possess the genetic mutation.

If you’re concerned about the risk of thyroid cancer and treatment options for younger patients, talk to a pediatric cancer specialist for a comprehensive discussion of the alternatives. Be sure to check back here each week for more of the thyroid health news you need.